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Electrochemically promoted thio-Michael addition of -substituted maleimides to thiols in an aqueous medium. | LitMetric

Electrochemically promoted thio-Michael addition of -substituted maleimides to thiols in an aqueous medium.

Org Biomol Chem

Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University Chengdu, Sichuan, 610031, China.

Published: July 2024

AI Article Synopsis

Article Abstract

A stable and practical electrochemical method was developed to promote the thio-Michael addition of -substituted maleimides to various thiols in an aqueous medium. This protocol was found to be excellent in terms of facile scale-up, oxidant- and catalyst-free conditions, broad substrate scopes, good functional group tolerance, and easily available substrates. Notably, a plausible reaction mechanism was derived from the results of a series of control experiments and CV studies, which indicated that a radical pathway might speed up the thio-Michael addition under constant current.

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Source
http://dx.doi.org/10.1039/d4ob00734dDOI Listing

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