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Ocular toxicity of psychotropic medications in a tertiary hospital in Lagos, Nigeria.
Rom J Ophthalmol
July 2024
Department of Behavioural Medicine, Lagos State University College of Medicine, Lagos State, Nigeria.
Article Synopsis
- * Various eye exams revealed additional problems: 20.3% showed lid pigmentation, 32.2% had cataracts, and 4.2% experienced peripheral retina degeneration, while Schirmer's test indicated varying levels of dry eyes among participants.
- * The research highlighted that long-term use and higher doses of psychotropic drugs could lead to serious eye-related side effects, affecting patients' overall quality of life and necessitating preventive measures against visual impairment.
Botulinum neurotoxin as early treatment in acute-onset lesional hemiballism.
Neurol Sci
July 2024
Neuroscience Head Neck Department, Azienda Ospedaliero-Universitaria Di Modena, Modena, Italy.
Background: Hemiballism (HB) and hemichorea (HC) are the most frequent secondary movement disorders, usually caused by cerebrovascular diseases. In only a minority of cases, these involuntary movements are not self-limited, and they may severely compromise patients' quality of life, so that symptomatic treatments are required. Typical and atypical neuroleptics as well as tetrabenazine are considered therapies of choice.
View Article and Find Full Text PDFThe effectiveness of very slow switching to aripiprazole in schizophrenia patients with dopamine supersensitivity psychosis: a case series from an open study.
Int Clin Psychopharmacol
November 2020
Department of Psychiatry, Chiba University Graduate School of Medicine.
Dopamine supersensitivity psychosis (DSP) in patients with schizophrenia is induced by treatment with a high dosage of antipsychotics for a long time period, and it is characterized by unstable psychotic symptoms. The upregulation of dopamine D2 receptor (DRD2) provoked by antipsychotics underlies DSP. Aripiprazole does not cause an excessive blockade of DRD2 and is less likely to upregulate DRD2 by aripiprazole's dopamine partial agonistic profile.
View Article and Find Full Text PDFShould we still monitor QTc duration in frail older patients on low-dose haloperidol? A prospective observational cohort study.
Age Ageing
August 2020
Cardiology Department, Maastricht University Medical Centre, Maastricht 6229 HX, The Netherlands.
Background: Haloperidol at high dosage is associated with QTc prolongation and polymorphic ventricular arrhythmia but the effects of low-dose haloperidol remain unknown.
Objective: To evaluate the effects of low-dose haloperidol on QTc-duration in frail hospitalized elderly patients with delirium.
Methods: A prospective observational study including hospitalized patients aged ≥70 years with Groningen Frailty Index-score > 3.
Treatment for Negative Symptoms in Schizophrenia: A Comprehensive Review.
Drugs
September 2017
Academic Medical Center, University of Amsterdam, Academic Psychiatric Centre, Early Psychosis Department, Arkin, Amsterdam, The Netherlands.
Negative symptoms (such as amotivation and diminished expression) associated with schizophrenia are a major health concern. Adequate treatment would mean important progress with respect to quality of life and participation in society. Distinguishing primary from secondary negative symptoms may inform treatment options.
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