AI Article Synopsis
- This study looked at how viruses in human semen can be spread during sex and how semen might affect that.
- Researchers found that human seminal plasma (SP) could kill certain infected cells and stop viruses like mumps from spreading to other cells.
- They discovered that different parts of the seminal plasma worked together to stop the virus, and that these effects were really strong even when the seminal plasma was treated to break it down.
Article Abstract
Viruses in human semen may be sexually transmitted via free and cell-mediated viral infection. The potential effects of semen on the infection and sexual transmission of most viruses in semen remain largely unclear. The present study elucidated the inhibitory effects of human seminal plasma (SP) on Jurkat cell (JC)-mediated mumps virus (MuV) infection. We demonstrated that MuV efficiently infected JCs and that the JCs infected by MuV (JC-MuV) mediated MuV infection of HeLa cells. Remarkably, SP was highly cytotoxic to JCs and inhibited JC-MuV infection of HeLa cells. The cytotoxic factor possessed a molecular weight of less than 3 kDa, whereas that of the viricidal factor was over 100 kDa. The cooperation of cytotoxic and viricidal factors was required for the SP inhibition of JC-MuV infection, and prostatic fluid (PF) was responsible for both the cytotoxic and viricidal effects of SP. The cytotoxic effects we observed were resistant to the treatment of PF with boiling water, proteinase K, RNase A, and DNase I. Our results provide novel insights into the antiviral properties of SP, which may limit cell-mediated sexual viral transmission.
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| http://dx.doi.org/10.1002/jmv.29733 | DOI Listing |
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Article Synopsis
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- They discovered that different parts of the seminal plasma worked together to stop the virus, and that these effects were really strong even when the seminal plasma was treated to break it down.
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