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Urate-lowering therapy in patients with hyperuricemia and heart failure: A retrospective cohort study using the UK Clinical Practice Research Datalink. | LitMetric

Urate-lowering therapy in patients with hyperuricemia and heart failure: A retrospective cohort study using the UK Clinical Practice Research Datalink.

Clin Cardiol

Global Medical Affairs, Clinical, Cardiovascular, Renal and Metabolic (CVRM), BioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden.

Published: June 2024

AI Article Synopsis

  • Elevated serum uric acid (sUA) levels are linked to higher risks of heart failure (HF), and urate-lowering therapy (ULT) may help reduce these risks.
  • A study analyzed data from patients with HF and high sUA levels, finding that those who received ULT had significantly lower risks of heart failure hospitalization and mortality after five years.
  • Ultimately, the research concluded that ULT could be beneficial for improving clinical outcomes in patients with both HF and elevated uric acid levels.

Article Abstract

Background: Elevated serum uric acid (sUA) is associated with heart failure (HF).

Hypothesis: Urate-lowering therapy (ULT) in HF is associated with lower risk of HF hospitalization (hHF) and mortality.

Methods: Data on patients with HF and gout or hyperuricemia in the Clinical Practice Research Datalink database linked to the Hospital Episode Statistics and the Office for National Statistics in the United Kingdom were analyzed. Risks of hHF and all-cause mortality or cardiovascular-related mortality by ULT exposure (ULT initiated within ≤6 months of gout or hyperuricemia diagnosis) were analyzed in a propensity score-matched cohort using adjusted Cox proportional hazards regression models.

Results: Of 2174 propensity score-matched pairs, patients were predominantly male, aged >70 years, with mean ± standard deviation sUA 9.3 ± 1.8 (ULT-exposed) and 9.4 ± 1.9 mg/dL (ULT-unexposed). At 5 years, ULT-exposed patients had a 43% lower risk of hHF or all-cause mortality (adjusted hazard ratio [HR]: 0.57; 95% confidence interval [CI]: 0.51-0.65) and a 19% lower risk of hHF or cardiovascular-related mortality (adjusted HR: 0.81; 95% CI: 0.71-0.92) versus no ULT exposure.

Conclusion: ULT was associated with reduced risk of adverse clinical outcomes in patients with HF and gout or hyperuricemia over 5 years.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177015PMC
http://dx.doi.org/10.1002/clc.24297DOI Listing

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