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Antiphospholipid syndrome is an autoimmune disease characterised by thrombotic and/or obstetric manifestations with persistent antiphospholipid antibodies. Diagnosis involves confirming the persistence of antiphospholipid antibodies in symptomatic patients, using validated classification criteria as a guide. The likelihood of obtaining false-positive or false-negative test results in certain settings, and the lack of standardisation between laboratory methods, are important considerations.
View Article and Find Full Text PDFCannabinoid hyperemesis syndrome in pregnancy: a case series and review.
Obstet Med
December 2024
Specialist Perinatal Mental Health Service, University Maternity Hospital Limerick, Limerick, Ireland.
Background: Cannabinoid hyperemesis syndrome (CHS) is a syndrome of cyclic nausea and vomiting in the setting of chronic cannabis use. To date, only 11 cases of CHS in pregnancy have been reported.
Case Presentation: We describe two cases of uncontrolled vomiting in pregnancy due to CHS.
[Translational Research on Pre-eclampsia with Existing Drugs Targeting Antioxidant Molecules].
Yakugaku Zasshi
January 2025
Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences.
Pre-eclampsia, a type of hypertensive disorders of pregnancy (HDP), is characterized by hypertension and organ dysfunction that develops or worsens after 20 weeks of gestation. Although symptomatic management using antihypertensive medications has been adopted, definitive treatments other than pregnancy termination remain unavailable to halt disease progression. Research on heme oxygenase (HO)-1, a molecule with anti-inflammatory and antioxidative properties, has shown that a pharmacological increase in placental HO-1 expression and activity may ameliorate this condition; therefore, HO-1 is a promising therapeutic target for this disorder.
View Article and Find Full Text PDFZika virus infections and associated risk factors among pregnant women in Gombe, Nigeria.
Virol Sin
December 2024
Department of Medical Laboratory Science, University of Maiduguri, College of Medical Sciences, P.M.B. 1069, Maiduguri, Nigeria. Electronic address:
Article Synopsis
- In-utero exposure to Zika virus (ZIKV) can result in severe outcomes like miscarriage and congenital Zika syndrome, prompting a study on the infection rates among pregnant women from February to April 2022.
- Researchers tested 200 pregnant women for ZIKV antibodies and found that 16.5% had ZIKV IgM, 10% had IgG, and 23% had neutralizing antibodies, indicating various stages of infection and immunity.
- The study also revealed that recent ZIKV infections were more common in sexually active women aged 20-29, with higher infection risks in first trimester and grand-multiparous women, although no significant link was found between ZIKV and specific pregnancy trimest
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