AI Article Synopsis
- Extranodal extension (ENE) is a key prognostic factor in various cancers, but its impact on pancreatic body/tail cancer (PBTC) was unclear, prompting this study to investigate its significance.
- Researchers analyzed electronic medical records of PBTC patients who had distal pancreatectomies from 2011 to 2015 and evaluated survival rates based on ENE presence using statistical methods.
- Results showed that PBTC patients with lymph node metastasis and ENE had significantly worse disease-free and overall survival rates, highlighting ENE's role as an important negative prognostic indicator that should be integrated into cancer staging systems for PBTC.
Article Abstract
Background/purpose: Extranodal extension (ENE) is an established prognostic factor in various malignancies, affecting survival in pancreatic head cancer (PHC). However, its significance in pancreatic body/tail cancer (PBTC) remains unclear. Therefore, we aimed to investigate the impact of ENE on PTBC prognosis.
Methods: We analyzed data collected from electronic medical records of patients with PBTC who underwent distal pancreatectomy at a single center between January 2011 and December 2015. The patients were categorized based on ENE presence and prognostic implications were evaluated using Kaplan-Meier survival curves and Cox proportional hazards model.
Results: PBTC cases involving lymph node (LN) metastasis and ENE exhibited significantly lower disease-free (DFS) and overall survival (OS) rates compared to cases without LN metastasis or ENE (median DFS; N0, 23 months; LN+/ENE-, 10 months; LN+/ENE+, 5 months; p < .001). No statistically significant difference was observed in DFS and OS rates between patients with N1/N2 in the group without ENE and those with ENE+. Multivariate analysis confirmed ENE as a significant adverse prognostic factor.
Conclusions: ENE significantly predicts poor prognosis in PBTC, particularly in cases with nodal metastasis. The current cancer staging system for PBTC should incorporate ENE status. Moreover, different staging systems should be considered for PHC and PBTC.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503450 | PMC |
| http://dx.doi.org/10.1002/jhbp.12008 | DOI Listing |
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