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A randomized phase III study evaluating dexamethasone-based mouthwash to prevent chemotherapy-induced stomatitis in patients with breast cancer.
Jpn J Clin Oncol
October 2024
Department of Breast and Medical Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.
Article Synopsis
- A multicenter phase III trial is being conducted to evaluate a dexamethasone-based mouthwash for preventing chemotherapy-induced stomatitis in early breast cancer patients.
- The study will involve 230 patients, randomly assigned to either the dexamethasone mouthwash group or a control group using tap water as mouthwash.
- The main goal is to measure the effectiveness of the mouthwash in reducing the incidence of stomatitis, tracked through electronic patient-reported outcomes.
Dexamethasone swish and spit: A cause of iatrogenic adrenal insufficiency.
Pediatr Blood Cancer
September 2024
Division of Pediatric Endocrinology and Diabetes, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA.
Dexamethasone solution and dexamethasone in Mucolox™ for the treatment of oral inflammatory ulcerative diseases: A phase II randomized clinical trial.
J Oral Pathol Med
October 2023
Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, California, USA.
Background: Mucolox™ is a mucosal drug delivery system that prolongs the contact time between the oral mucosa and topical corticosteroids, potentially reducing the need for multiple applications daily. This study aimed to assess the clinical efficacy and tolerability of dexamethasone 0.5 mg/5 mL solution in Mucolox™ for the management of oral inflammatory ulcerative diseases.
View Article and Find Full Text PDFA randomized clinical trial of topical dexamethasone vs. cyclosporine treatment for oral lichen planus.
Med Oral Patol Oral Cir Bucal
March 2022
Department of Oral Medicine and Pathology and Hospital Dentistry School of Dentistry, National and Kapodistrian University of Athens 2 Thivon St., Goudi 11527, Athens, Greece
Background: Oral lichen planus (OLP) is a common, frequently symptomatic, immune-mediated disease. Various treatments have been used for symptomatic OLP, including corticosteroids and immunosuppressants administered topically or systemically. The aim of this study was to compare the effectiveness of topical dexamethasone vs.
View Article and Find Full Text PDFStudy protocol for efficacy and safety of steroid-containing mouthwash to prevent chemotherapy-induced stomatitis in women with breast cancer: a multicentre, open-label, randomised phase 2 study.
BMJ Open
February 2020
Surgery, Nagasaki University School of Medicine Graduate School of Biomedical Sciences, Nagasaki, Japan.
Introduction: Stomatitis is a frequent adverse event in patients undergoing chemotherapy for breast cancer. Stomatitis can hamper oral nutrition resulting in malnutrition, reduce quality of life and introduce the need for dose reductions and interruption of chemotherapy; however, there is currently no standard approach for preventing chemotherapy-induced stomatitis. We aimed to assess the safety and efficacy of a dexamethasone-based elixir mouthwash for preventing chemotherapy-induced stomatitis in patients with early breast cancer.
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