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Association of volatile organic compound metabolites with hearing loss: unveiling their potential mechanism and intervention target.
Environ Sci Process Impacts
January 2025
Department of Otorhinolaryngology, No. 971 Hospital of People's Liberation Army Navy, Qingdao 266000, Shandong Province, China.
Hearing loss (HL) is an otolaryngology disease susceptible to environmental pollutants. Volatile organic compounds (VOCs), as a class of chemical pollutants with evaporation propensity, pose a great threat to human health. However, the association between VOCs and HL remains unclear.
View Article and Find Full Text PDFComprehensive bioinformatics analysis identifies hub genes associated with immune cell infiltration in early-onset schizophrenia.
BMC Psychiatry
January 2025
The Fifth Hospital of Shanxi Medical University, The Fifth Clinical Medical College of Shanxi Medical University, Shanxi Provincial People's Hospital, Taiyuan, 030032, China.
Background: Early-onset schizophrenia (EOS) occurs between the ages of 13 and 17 years, and neurobiological factors leading to cognitive deficits and psychotic symptoms with varying degrees of positive and negative symptoms. Numerous studies have demonstrated a broad link between immune dysregulation and the central nervous system in EOS, and its pathogenesis involves immune dysfunction, but the exact biological mechanisms have not been elucidated. This study employs immune infiltration analysis and bioinformatics to unveil the pathogenic mechanisms of EOS and identify potential diagnostic biomarkers, aiming for more precise clinical interventions.
View Article and Find Full Text PDFIntegration of CRISPR/dCas9-Based methylation editing with guide positioning sequencing identifies dynamic changes of mrDEGs in breast cancer progression.
Cell Mol Life Sci
January 2025
Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Dynamic changes in DNA methylation are prevalent during the progression of breast cancer. However, critical alterations in aberrant methylation and gene expression patterns have not been thoroughly characterized. Here, we utilized guide positioning sequencing (GPS) to conduct whole-genome DNA methylation analysis in a unique human breast cancer progression model: MCF10 series of cell lines (representing benign/normal, atypical hyperplasia, and metastatic carcinoma).
View Article and Find Full Text PDFDensely populated countries have higher demand for agricultural products and greater use of fuel and vehicles, resulting in higher environmental emissions, so this study considers transportation infrastructure and the agricultural sector as the two major drivers of environmental degradation in the top five densely populated countries. In a baseline regression, this study first unveils the impact of investments in transportation infrastructure, agricultural value addition, and environment-related technologies on per capita CO emissions using CS-ARDL approach from 1990 to 2021 in the five most populous countries. Besides, this study also reveals the typical moderating effect of environment-related technologies in the link between transport infrastructure, agricultural value added and environmental hazards.
View Article and Find Full Text PDFAsthma-associated prostate enlargement and bladder smooth muscle hypercontractility: unveiling a potential link to LUTS.
BMC Urol
January 2025
Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510230, China.
Background: In male patients, benign prostate hyperplasia (BPH) and overactive bladder (OAB) secondary to BPH are the primary causes of Lower Urinary Tract Symptoms (LUTS). Recent clinical studies have reported an increased risk of LUTS, particularly severe LUTS conditions, in male asthmatic patients. However, the potential link and mechanism remain unclear.
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