AI Article Synopsis

  • Helicobacter pylori is a major gastrointestinal pathogen that poses health risks due to antibiotic resistance, highlighting the need for alternative treatments.
  • This study investigates the effects of Limosilactobacillus fermentum T0701 cell-free supernatants (LCFS) against H. pylori, finding that it has significant antimicrobial activity and can inhibit the bacteria effectively.
  • LCFS demonstrates safety, as it shows no toxicity to human gastric cells and possesses no virulence or resistance genes, making it a promising non-toxic option for preventing H. pylori infections.

Article Abstract

Helicobacter pylori is a prominent gastrointestinal pathogen associated with various gastrointestinal illnesses. It presents substantial health risks due to its antibiotic resistance. Therefore, it is crucial to identify alternative treatments for H. pylori infections. Limosilactobacillus spp exhibit probiotic properties with beneficial effects in humans; however, the mechanisms by which it counteracts H. pylori infection are unknown. This study aimed to evaluate the potential of Limosilactobacillus fermentum T0701 lyophilized cell-free supernatants (LCFS) against H. pylori. The LCFS has varying antimicrobial activities, with inhibition zones of up to 10.67 mm. The minimum inhibitory concentration and minimum bacterial concentration of LCFS are 6.25-25.00 mg/mL and 6.25 mg/mL to > 50.00 mg/mL, respectively, indicating its capability to inhibit H. pylori. There is morphological damage observed in H. pylori treated with LCFS. Additionally, H. pylori adhesion to AGS cells (human gastric adenocarcinoma epithelial cells) reduces by 74.23%, highlighting the LCFS role in preventing bacterial colonization. Moreover, LCFS exhibits no cytotoxicity or morphological changes in AGS cells, and with no detected virulence or antimicrobial resistance genes, further supporting its safety profile. L. fermentum T0701 LCFS shows promise as a safe and effective non-toxic agent against H. pylori, with the potential to prevent gastric colonization.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11176309PMC
http://dx.doi.org/10.1038/s41598-024-64443-4DOI Listing

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Article Synopsis
  • Helicobacter pylori is a major gastrointestinal pathogen that poses health risks due to antibiotic resistance, highlighting the need for alternative treatments.
  • This study investigates the effects of Limosilactobacillus fermentum T0701 cell-free supernatants (LCFS) against H. pylori, finding that it has significant antimicrobial activity and can inhibit the bacteria effectively.
  • LCFS demonstrates safety, as it shows no toxicity to human gastric cells and possesses no virulence or resistance genes, making it a promising non-toxic option for preventing H. pylori infections.
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