AI Article Synopsis
- The text discusses the historical context of monkeypox outbreaks originating from different clades in Africa, particularly focusing on a recent outbreak in the Democratic Republic of the Congo caused by clade I MPXV.
- Surveillance data collected from September 2023 to January 2024 identified 241 suspected cases, with genomic analysis revealing a new lineage distinct from prior strains in the area.
- The median age of confirmed cases was 22 years, with a significant portion being female and sex workers, hinting at potential sexual transmission; ongoing mutations suggest recent human-to-human spread.
Article Abstract
Outbreaks of monkeypox (mpox) have historically resulted from zoonotic spillover of clade I monkeypox virus (MPXV) in Central Africa and clade II MPXV in West Africa. In 2022, subclade IIb caused a global epidemic linked to transmission through sexual contact. Here we describe the epidemiological and genomic features of an mpox outbreak in a mining region in eastern Democratic Republic of the Congo, caused by clade I MPXV. Surveillance data collected between September 2023 and January 2024 identified 241 suspected cases. Genomic analysis demonstrates a distinct clade I lineage divergent from previously circulating strains in the Democratic Republic of the Congo. Of the 108 polymerase chain reaction-confirmed mpox cases, the median age of individuals was 22 years, 51.9% were female and 29% were sex workers, suggesting a potential role for sexual transmission. The predominance of APOBEC3-type mutations and the estimated emergence time around mid-September 2023 imply recent sustained human-to-human transmission.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485229 | PMC |
| http://dx.doi.org/10.1038/s41591-024-03130-3 | DOI Listing |
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