AI Article Synopsis
- - The study analyzed malaria epidemiology in Gabon from 1980 to 2023 using five databases to track prevalence, drug resistance, and insecticide resistance markers.
- - Gabon faces a significant public health challenge with high malaria rates, showing persistent resistance to chloroquine (CQ) and emerging resistance to sulfadoxine-pyrimethamine (SP), while artemisinin-based combination therapies (ACTs) remain effective.
- - Recent findings indicate a high frequency of insecticide resistance markers, with alternatives like organophosphates and carbamates suggested for vector control.
Article Abstract
The objective of this were conducted to elucidate spatiotemporal variations in malaria epidemiology in Gabon since 1980. For that, five databases, were used to collect and identify all studies published between 1980 and 2023 on malaria prevalence, antimalarial drug resistance, markers of antimalarial drug resistance and insecticide resistance marker. The findings suggest that Gabon continues to face malaria as an urgent public health problem, with persistently high prevalence rates. Markers of resistance to CQ persist despite its withdrawal, and markers of resistance to SP have emerged with a high frequency, reaching 100 %, while ACTs remain effective. Also, recent studies have identified markers of resistance to the insecticides Kdr-w and Kdr-e at frequencies ranging from 25 % to 100 %. Ace1R mutation was reported with a frequency of 0.4 %. In conclusion, the efficacy of ACTs remains above the threshold recommended by the WHO. Organo-phosphates and carbamates could provide an alternative for vector control.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jiph.2024.05.047 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!