This paper describes an important problem of aerospace medicine, i. e. space motion sickness. The review surveys relevant Soviet and foreign publications. On their basis, including their own data, the authors discuss possible mechanisms of the sickness symptom-complex in the weightless state. The authors put forth their own ideas concerning current hypotheses of space motion sickness and discuss potential applicability of the theoretical concepts with respect to the prevention of this adverse symptom-complex. The authors describe selected outlines in the study of mechanisms of space motion sickness and in the development of specific countermeasures.

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