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Redefining Vaginal Agenesis Management: A Comprehensive Review.
Cureus
December 2024
Prosthodontics, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Vaginal agenesis, a rare and complex congenital anomaly predominantly linked to Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome or complete androgen insensitivity syndrome (CAIS), demands innovative and highly individualized treatment strategies to achieve anatomical and functional restoration. While non-surgical options like vaginal dilation remain foundational, the advent of custom-made stents has redefined the paradigm of care, emerging as a transformative tool in both post-surgical and non-surgical management. Bridging the expertise of prosthodontics and gynecology, personalized stents not only enhance healing and maintain patency but also elevate patient comfort and compliance.
View Article and Find Full Text PDFA Comprehensive Survey of Deep Learning Approaches in Image Processing.
Sensors (Basel)
January 2025
Industrial Systems Institute (ISI), Athena Research and Innovation Center, 26504 Patras, Greece.
The integration of deep learning (DL) into image processing has driven transformative advancements, enabling capabilities far beyond the reach of traditional methodologies. This survey offers an in-depth exploration of the DL approaches that have redefined image processing, tracing their evolution from early innovations to the latest state-of-the-art developments. It also analyzes the progression of architectural designs and learning paradigms that have significantly enhanced the ability to process and interpret complex visual data.
View Article and Find Full Text PDFArtificial intelligence in drug development.
Nat Med
January 2025
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Drug development is a complex and time-consuming endeavor that traditionally relies on the experience of drug developers and trial-and-error experimentation. The advent of artificial intelligence (AI) technologies, particularly emerging large language models and generative AI, is poised to redefine this paradigm. The integration of AI-driven methodologies into the drug development pipeline has already heralded subtle yet meaningful enhancements in both the efficiency and effectiveness of this process.
View Article and Find Full Text PDFIntra-tumoral bacteria in breast cancer and intervention strategies.
Adv Drug Deliv Rev
January 2025
NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou 510515, China. Electronic address:
The microbiome, consisting of a wide range of both beneficial and harmful microorganisms, is vital to various physiological and pathological processes in the human body, including cancer pathogenesis. Tumor progression is often accompanied by the destruction of the vascular system, allowing bacteria to circulate into the tumor area and flourish in an immunosuppressive environment. Microbes are recognized as significant components of the tumor microenvironment.
View Article and Find Full Text PDF"Encouraged to be Your True Self": An Interpretative Phenomenological Study of Medical Students' Experiences of Role Models in Shaping Sexual Minority Identity in Medical School.
Teach Learn Med
January 2025
Department of Education, University of Oxford, Oxford, UK.
Sexual and gender minority (SGM) identifying individuals experience worse health outcomes compared to non-SGM identifying counterparts. Representation of SGM individuals within medical schools may improve the delivery of more equitable healthcare through reducing biases and normalizing SGM presence within healthcare spaces. Our initial aim was to explore the extent to which role models may influence personal SGM identities within medical schools in the United Kingdom, using an interpretative phenomenological approach.
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