High methylation of the same promoter of lncRNA / promotes malignant progression of esophageal cancer.

This study aimed to investigate the functions of and in esophageal cancer (EC). Bioinformatics analysis, qRT-PCR and western blot were used to analyze the expression levels. Biological functions were evaluated using cell-counting kit 8, colony formation, Transwell assays and flow cytometry. FISH was used to detect subcellular localization, and methylation-specific PCR determined gene methylation levels. Animal experiments validated the impact on tumor progression. and were highly methylated and downregulated in EC. Overexpression of up-regulated the expression of , thereby inhibiting EC cell viability and metastasis, promoting apoptosis and inhibiting tumor growth. Low expression of / mediated by DNA hypermethylation facilitates the malignant progression of EC.