AI Article Synopsis
- Gut microbiota helps keep our immune system balanced, especially when fighting off bad bacteria!
- It plays a tricky role in cancer, affecting both how cancers grow and how well cancer treatments work!
- Scientists are exploring how changing the types of bacteria in our gut might make cancer treatments more effective or reduce side effects!
Article Abstract
Gut microbiota is essential for maintaining local and systemic immune homeostasis in the presence of bacterial challenges. It has been demonstrated that microbiota play contrasting roles in cancer development as well as anticancer immunity. Cancer immunotherapy, a novel anticancer therapy that relies on the stimulation of host immunity, has suffered from a low responding rate and incidence of severe immune-related adverse events (irAEs). Previous studies have demonstrated that the diversity and composition of gut microbiota were associated with the heterogeneity of therapeutic effects. Therefore, alteration in microbiota taxa can lead to improved clinical outcomes in immunotherapy. In this review, we determine whether microbiota composition or microbiota-derived metabolites are linked to responses to immunotherapy and irAEs. Moreover, we discuss various approaches to improve immunotherapy efficacy or reduce toxicities by modulating microbiota composition.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10989143 | PMC |
| http://dx.doi.org/10.1002/imt2.156 | DOI Listing |
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