AI Article Synopsis
- A high-salt diet in mice leads to cognitive issues and reduced synaptic protein levels due to changes in gut microbiota and short-chain fatty acid production.
- Mice with gut microbiota from high-salt diet-fed mice show impaired memory and synapse function when placed on a regular diet.
- Treatment with butyrate, a short-chain fatty acid, helps improve memory impairments in mice that were on a high-salt diet, highlighting the gut microbiome's significant role in cognitive health.
Article Abstract
High-salt diet (HSD)-fed mice display cognitive impairment and lower synaptic proteins via changed gut microbiota composition and short-chain fatty acids production. Gut microbiota from HSD-fed mice impairs memory and synapse in normal salt diet-fed mice. Butyrate treatment partially reverses memory impairment in HSD-fed mice. Above all, this study indicates the important role of the gut microbiome and butyrate production in synaptic loss and memory impairment.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10989808 | PMC |
| http://dx.doi.org/10.1002/imt2.97 | DOI Listing |
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