The article aims to explore the challenges involved in diagnosing and managing Alice in Wonderland Syndrome (AIWS) in pediatric cases, focusing on an eight-year-old female with perceptual distortions affecting vision, hearing, and time perception. AIWS, a rare neurological phenomenon, manifests as distortions in the perception of the body and external stimuli. The lack of established diagnostic criteria, particularly in the pediatric population, complicates accurate identification. The presented case illustrates visual anomalies, auditory abnormalities, and tachysensia, emphasizing the multisensory nature of AIWS. The temporal association with underlying causes, such as migraines and viral infections, highlights the need for a comprehensive evaluation. The Acharya Vinoba Bhave Rural Hospital management approach involves a systematic assessment, identification of underlying chronic conditions, and targeted treatment. Migraine prophylaxis, utilizing prescription drugs and a low-tyramine diet, plays a central role. The limited use of antipsychotics underscores the neurological origin of AIWS. The article contributes valuable insights into pediatric AIWS, advocating for further research and awareness. The article also aims to highlight the lack of established diagnostic criteria for AIWS, particularly in the pediatric population, and to present a systematic management approach based on a specific case study. The multidisciplinary collaboration, regular follow-ups, and patient education constitute a comprehensive approach to enhance understanding and alleviate symptoms in AIWS cases.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167684PMC
http://dx.doi.org/10.7759/cureus.60182DOI Listing

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Article Synopsis
  • Alice in Wonderland syndrome (AIWS) is a neurological condition that distorts perception across various senses and time, and this text presents two pediatric cases linked with SARS-CoV-2 infection.
  • Both cases involved young girls experiencing unusual visual and auditory distortions during and after a COVID-19 infection, with symptoms resolving following negative SARS-CoV-2 tests.
  • The authors suggest that COVID-19 may contribute to AIWS symptoms and recommend considering it in children with hallucinations, emphasizing a complex relationship between inflammation and neurological effects.
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