Multi-focal intra-ocular or contact lenses, intended to increase depth of focus, conventionally have annular zones of additional refractive power, generating wavefront rings of coaxial spherical surfaces. It is, however, possible to influence depth of focus by changing not only the curvature of the wavefront, refractive power, in the annulus, but also the tilt, circularly symmetrical linear radial deviation imposed on the spherical wavefront. Employing the example of a single annulus bifocal, retinal image light distributions in the two regimes are calculated, using standard diffraction theory. Four measures of retinal image quality in through-focus scans show that plus power additions and wavefront tilts operate almost interchangeably. In testing these lenses, attention needs to be paid to the detailed operating characteristics of measuring devices of the Shack-Hartmann type to ensure that their grain and precision is compatible with the framework of the analysis.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166445 | PMC |
http://dx.doi.org/10.1364/BOE.525766 | DOI Listing |
Biol Imaging
December 2024
Visual Information Laboratory, University of Bristol, Bristol, UK.
Optical coherence tomography (OCT) and confocal microscopy are pivotal in retinal imaging, offering distinct advantages and limitations. OCT offers rapid, noninvasive imaging but can suffer from clarity issues and motion artifacts, while confocal microscopy, providing high-resolution, cellular-detailed color images, is invasive and raises ethical concerns. To bridge the benefits of both modalities, we propose a novel framework based on unsupervised 3D CycleGAN for translating unpaired OCT to confocal microscopy images.
View Article and Find Full Text PDFJ CME
January 2025
DKBmed, New York, NY, USA.
Diabetic retinopathy (DR) is a public health issue affecting millions in the United States and Europe. However, despite strong recommendations for screening at regular intervals by many professional societies, including the American Diabetes Association and the American Academy of Ophthalmology, screening rates remain suboptimal, with only 50-70% of patients with diabetes adhering to recommended annual eye exams. Barriers to screening include lack of awareness, socioeconomic factors, health care system fragmentation, and workforce shortages, among others.
View Article and Find Full Text PDFJAMA Psychiatry
January 2025
Max Planck Institute of Psychiatry, Munich, Germany.
Importance: As an accessible part of the central nervous system, the retina provides a unique window to study pathophysiological mechanisms of brain disorders in humans. Imaging and electrophysiological studies have revealed retinal alterations across several neuropsychiatric and neurological disorders, but it remains largely unclear which specific cell types and biological mechanisms are involved.
Objective: To determine whether specific retinal cell types are affected by genomic risk for neuropsychiatric and neurological disorders and to explore the mechanisms through which genomic risk converges in these cell types.
Geroscience
January 2025
Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
With the development of deep learning (DL) techniques, there has been a successful application of this approach to determine biological age from latent information contained in retinal images. Retinal age gap (RAG) defined as the difference between chronological age and predicted retinal age has been established previously to predict the age-related disease. In this study, we performed discovery genome-wide association analysis (GWAS) on the RAG using the 31,271 UK Biobank participants and replicated our findings in 8034 GoDARTS participants.
View Article and Find Full Text PDFCurr Atheroscler Rep
January 2025
Department of Ophthalmology, NYU Langone Medical Center, New York, USA.
Purpose Of Review: Cardiovascular disease (CVD) is a leading cause of preventable morbidity and mortality globally, and retinal imaging modalities (old and new) are being explored as noninvasive tools to predict latent atherosclerosis and cardiovascular disease. This review focuses on the emerging promise of fundoscopy, optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA) in CVD prognostication.
Recent Findings: High-quality studies have established the utility of vessel-based parameters and discrete conditions diagnosable via fundoscopy in subclinical atherosclerosis detection or CVD prediction.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!