AI Article Synopsis
- Two new xanthones, xanthoschomes A and B, were discovered from Vietnamese fruit, alongside six known xanthones.
- All compounds were thoroughly characterized using spectroscopic methods and literature comparisons.
- The new compounds showed significant inhibition of alpha-glucosidase, particularly one with an IC value of 2.91 M, which was much more effective than the standard treatment, acarbose (IC 179 M).
Article Abstract
Two previously unreported xanthones, xanthoschomes A and B ( and ), along with six known xanthones, -mangostin (), -mangostin (), -mangostin (), garcinone C (), 2-(,-dimethylallyl)-1,7-dihydroxy-3-methoxyxanthone (), and dulxanthone D (), have been isolated from the fruits of Vietnamese The structures of all isolated compounds were fully characterised using spectroscopic data and comparison with the previous literature. All isolated compounds were evaluated for their -glucosidase inhibitory activity. Compounds demonstrated effective -glucosidase inhibition, with the IC ranging from 2.91 to 26.0 M, outperforming the standard acarbose (IC 179 M). Among these isolated compounds, compound exhibited the highest inhibitory activity against -glucosidase, with an IC value of 2.91 M.
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| http://dx.doi.org/10.1080/14786419.2024.2367011 | DOI Listing |
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