AI Article Synopsis
- Tinospora sagittata is a medicinal plant in the Menispermaceae family, known for its tuber's use in traditional Chinese medicine, which is high in valuable compounds like diterpenoids and alkaloids.
- Researchers created a detailed, high-quality genome for T. sagittata using advanced sequencing techniques, producing a genome size of 2.33 Gb with 4483 contigs.
- This genome assembly is significant as it's the first of its kind for the Menispermaceae family, contributing to the understanding of the plant's evolution and the biosynthesis of its medicinal compounds.
Article Abstract
Tinospora sagittata (Oliv.) Gagnep. is an important medicinal tetraploid plant in the Menispermaceae family. Its tuber, Radix Tinosporae, used in traditional Chinese medicine, is rich in diterpenoids and benzylisoquinoline alkaloids (BIAs). To enhance our understanding of medicinal compounds' biosynthesis and Menispermaceae's evolution, we herein report assembling a high-quality chromosome-scale genome with both PacBio HiFi and Illumina sequencing technologies. PacBio Sequel II generated 2.5 million circular consensus sequencing (CCS) reads, and a hybrid assembly strategy with Illumina sequencing resulted in 4483 contigs. The assembled genome size was 2.33 Gb, consisting of 4070 scaffolds (N50 = 42.06 Mb), of which 92.05% were assigned to 26 pseudochromosomes. T. sagittata's chromosomal-scale genome assembly, the first species in Menispermaceae, aids Menispermaceae evolution and T. sagittata's secondary metabolites biosynthesis understanding.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11169364 | PMC |
| http://dx.doi.org/10.1038/s41597-024-03315-y | DOI Listing |
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