Electrochemotherapy (ECT) is a treatment modality that combines the electroporation of cell membranes with chemotherapy to facilitate the transport of non-permeant molecules into cells. Several canine and feline studies have shown promising results, suggesting that ECT can be a valid adjuvant or alternative treatment option for some tumours. The objective of this paper is to provide a bibliographic review of the principles and applications of ECT in veterinary medicine and to compare to its use in human medicine.
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Electrochemotherapy in dogs and cats-A review.
Vet Comp Oncol
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Institute of Biomedical Sciences Abel Salazar, Porto, Portugal.
Electrochemotherapy (ECT) is a treatment modality that combines the electroporation of cell membranes with chemotherapy to facilitate the transport of non-permeant molecules into cells. Several canine and feline studies have shown promising results, suggesting that ECT can be a valid adjuvant or alternative treatment option for some tumours. The objective of this paper is to provide a bibliographic review of the principles and applications of ECT in veterinary medicine and to compare to its use in human medicine.
View Article and Find Full Text PDFComparison of Nucleosome, Ferritin and LDH Levels in Blood with Clinical Response before and after Electrochemotherapy Combined with IL-12 Gene Electrotransfer for the Treatment of Mast Cell Tumours in Dogs.
Animals (Basel)
January 2024
Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.
Electrochemotherapy (ECT) in combination with the gene electrotransfer of interleukin 12 (IL-12 GET) has been successfully used in veterinary medicine for the treatment of mast cell tumours (MCT), but the biomarkers that could predict response to this treatment have not yet been investigated. The aim of this study was to determine the plasma nucleosome and serum ferritin concentrations, as well as the lactate dehydrogenase (LDH) activity, in the serum of treated patients before and one and six months after treatment to evaluate their utility as potential biomarkers that could predict response to the combined treatment. The study was conducted in 48 patients with a total of 86 MCTs that we treated with the combined treatment.
View Article and Find Full Text PDFEvaluation of the safety and feasibility of electrochemotherapy with intravenous bleomycin as local treatment of bladder cancer in dogs.
Sci Rep
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School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP) "Júlio de Mesquita Filho", Jaboticabal, São Paulo, Brazil.
Local treatment of canine urothelial carcinoma (UC) of the bladder is a challenge. More than 90% of the cases invade the muscular layer, more than 50% develop on bladder sites with a difficult surgical approach and often requiring radical surgical procedures. This study aims to evaluate the safety and feasibility of electrochemotherapy (ECT) with intravenous bleomycin (BLM) as a local therapy for bladder UC.
View Article and Find Full Text PDFAdjuvant electrochemotherapy of malignant ocular melanoma in a dog.
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View Article and Find Full Text PDFTreatment of spontaneous canine mast cell tumors by electrochemotherapy combined with IL-12 gene electrotransfer: Comparison of intratumoral and peritumoral application of IL-12.
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July 2023
Veterinary Faculty, University of Ljubljana, Gerbiceva 60, 1000 Ljubljana, Slovenia. Electronic address:
Article Synopsis
- The clinical trial compared two methods of delivering interleukin-12 (IL-12) gene electrotransfer (GET) in combination with electrochemotherapy (ECT) to treat spontaneous mast cell tumors (MCTs) in dogs, focusing on intratumoral (i.t.) vs. peritumoral (peri.t.) administration.
- Results indicated that the i.t. administration of IL-12 GET showed significantly better local tumor control and longer disease-free and progression-free survival compared to both peri.t. and ECT alone groups.
- Immunological tests confirmed a notable increase in antitumor immune cells in the i.t. group, reinforcing the effectiveness of this treatment method without severe side effects, leading
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