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General theoretical aspects (classification of circulatory disorders and heart failure) and results of research into specific subdivisions of cardiovascular and respiratory system pathology in cardiac surgical patients are discussed. The material is aggregated by the applied clinico-mathematical approach that has been developed and introduced into clinical practice in the recent 15 years at the Bakulev Institute of Cardiovascular Surgery. The extension of the clinico-mathematical approach onto the intraoperative control and analysis of the patients' status, assessment of the anaesthetic administration and cardioplegic protection is first overviewed.

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The structure of cyclic depressions and the efficacy of various types of therapy were studied using clinico-mathematical methods. A computerized cluster analysis revealed statistically significant ratios between individual symptoms making up the clinical picture of the depressive state and the results of one of the three variants of therapy: tricyclic antidepressants, monoamine oxidase inhibitors and one-stage withdrawal of psychotropic agents. The results obtained made it possible to objectively evaluate the selection of the therapeutic procedure in the treatment of various depressive states.

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