Bacterial lipopolysaccharide (LPS) is implicated in disrupting the blood-brain barrier (BBB). In a recent issue of Nature, Wei et al. now show that LPS activates the inflammatory caspases (4, 5, and 11) and gasdermin D (GSDMD) in brain endothelial cells, which triggers their pyroptotic cell death and disrupts the BBB.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495843 | PMC |
| http://dx.doi.org/10.1016/j.immuni.2024.05.012 | DOI Listing |
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