AI Article Synopsis
- Large scale outbreaks of infectious respiratory diseases caused by evolving RNA viruses are becoming more severe and harder to control with current vaccines and treatments.
- Germicidal UV-C is an effective disinfection method that can inactivate RNA viruses, and its effectiveness has been linked to genomic damage in the viruses.
- This study finds that larger genomic damage correlates with increased inactivation of RNA viruses, suggesting even minimal damage can suffice to render them inactive.
Article Abstract
Large scale outbreaks of infectious respiratory disease have repeatedly plagued the globe over the last 100 years. The scope and strength of the outbreaks are getting worse as pathogenic RNA viruses are rapidly evolving and highly evasive to vaccines and anti-viral drugs. Germicidal UV-C is considered as a robust agent to disinfect RNA viruses regardless of their evolution. While genomic damage by UV-C has been known to be associated with viral inactivation, the precise relationship between the damage and inactivation remains unsettled as genomic damage has been analyzed in small areas, typically under 0.5 kb. In this study, we assessed genomic damage by the reduced efficiency of reverse transcription of regions of up to 7.2 kb. Our data seem to indicate that genomic damage was directly proportional to the size of the genome, and a single hit of damage was sufficient for inactivation of RNA viruses. The high efficacy of UV-C is already effectively adopted to inactivate airborne RNA viruses.
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| http://dx.doi.org/10.1016/j.jphotobiol.2024.112949 | DOI Listing |
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