AI Article Synopsis
- Effective osteointegration is crucial for pedicle screws used in spinal fusion surgeries, as current screws often lack osteoinductive activity, leading to common complications like screw loosening.
- Researchers developed Ti-6Al-4V pedicle screws using selective laser melting (SLM) and applied porous oxide coatings to enhance their surface properties.
- A goat model showed that these modified screws improved bone maturation and osseointegration, suggesting a promising approach for better orthopedic internal fixation.
Article Abstract
Effective osteointegration is of great importance for pedicle screws in spinal fusion surgeries. However, the lack of osteoinductive activity of current screws diminishes their feasibility for osteointegration and fixation, making screw loosening a common complication worldwide. In this study, Ti-6Al-4V pedicle screws with full through-hole design were fabricated via selective laser melting (SLM) 3D printing and then deposited with porous oxide coatings by microarc oxidation (MAO). The porous surface morphology of the oxide coating and the release of bioactive ions could effectively support cell adhesion, migration, vascularization, and osteogenesis . Furthermore, an goat model demonstrated the efficacy of modified screws in improving bone maturation and osseointegration, thus providing a promising method for feasible orthopedic internal fixation.
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| http://dx.doi.org/10.1021/acsami.4c03628 | DOI Listing |
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