AI Article Synopsis
- Chronic retinal necrosis is characterized by severe retinal inflammation and has been noted in patients with mild immune issues and conditions like CMV uveitis, often with negative HIV tests.
- Two specific cases are reported involving an 85-year-old woman and a 76-year-old man, both showing symptoms of advanced retinal disease related to long-term necrotizing retinitis.
- Testing revealed no herpesviruses but confirmed the presence of Toxoplasma gondii, suggesting that this organism should be included in the diagnosis for elderly patients with chronic retinal necrosis.
Article Abstract
Introduction: Chronic retinal necrosis encompasses severe occlusive retinal vasculitis, granular retinitis, and vitritis. This phenotype has been observed in patients with limited immune dysfunction, cytomegalovirus (CMV) uveitis, and negative serology for human immunodeficiency virus (HIV).
Methods: Case series.
Results: We present two cases: an 85-year-old female and a 76-year-old male, both displaying unusual occlusive panretinal vasculopathy associated with long-standing necrotizing retinitis and vitritis. Anterior chamber taps with real-time polymerase chain reaction (PCR) were negative for herpesviruses and positive for Toxoplasma gondii in both cases. These findings are consistent with chronic retinal necrosis associated with toxoplasma gondii.
Conclusions: In elderly patients or those with limited immune dysfunction who present with chronic retinal necrosis, Toxoplasma gondii should be considered in the differential diagnosis.
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| http://dx.doi.org/10.1080/09273948.2024.2362876 | DOI Listing |
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