AI Article Synopsis
- The cortex and cerebellum have complex reciprocal connections, and this study explores how individual cerebellar neurons connect with the broader mouse dorsal cortex using advanced imaging techniques.
- Cortical responses to cerebellar neurons differ greatly, depending on brain states, yet these responses are rooted in a shared network across the cortex.
- Specific types of spikes from Purkinje cells show distinct patterns of connectivity, with complex spikes linking mainly to the sensorimotor cortex, while simpler spikes exhibit a broader range of connections, and all of this connectivity shifts between anesthesia and awake states.
Article Abstract
The cortex and cerebellum form multi-synaptic reciprocal connections. We investigate the functional connectivity between single spiking cerebellar neurons and the population activity of the mouse dorsal cortex using mesoscale imaging. Cortical representations of individual cerebellar neurons vary significantly across different brain states but are drawn from a common set of cortical networks. These cortical-cerebellar connectivity features are observed in mossy fibers and Purkinje cells as well as neurons in different cerebellar lobules, albeit with variations across cell types and regions. Complex spikes of Purkinje cells preferably associate with the sensorimotor cortex, whereas simple spikes display more diverse cortical connectivity patterns. The spontaneous functional connectivity patterns align with cerebellar neurons' functional responses to external stimuli in a modality-specific manner. The tuning properties of subsets of cerebellar neurons differ between anesthesia and awake states, mirrored by state-dependent changes in their long-range functional connectivity patterns with mesoscale cortical activity.
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| http://dx.doi.org/10.1016/j.celrep.2024.114348 | DOI Listing |
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