Understanding the neural correlates of unconscious perception stands as a primary goal of experimental research in cognitive psychology and neuroscience. In this Perspectives paper, we explain why experimental protocols probing qualitative dissociations between perception and action provide valuable insights into conscious and unconscious processing, along with their corresponding neural correlates. We present research that utilizes human eye movements as a sensitive indicator of unconscious visual processing. Given the increasing reliance on oculomotor and pupillary responses in consciousness research, these dissociations also provide a cautionary tale about inferring conscious perception solely based on no-report protocols.
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http://dx.doi.org/10.1162/jocn_a_02122 | DOI Listing |
Rheumatology (Oxford)
January 2025
Department of Rheumatology, Acute Rheumatology Centre Rhineland-Palatinate, Bad Kreuznach, Germany.
Objective: To examine the longitudinal associations of optical spectral transmission (OST) with clinical inflammatory arthritis activity markers in order to investigate its potential in monitoring disease activity.
Methods: OST measurements were performed in 1,312 wrist and finger joints of 60 patients with clinical suspicion of inflammatory activity, within the context of known rheumatic inflammatory diseases at two separate time intervals. In each time point, patients underwent additional clinical and laboratory examinations.
J Phys Chem A
January 2025
Institute of Modern Physics, Shaanxi Key Laboratory for Theoretical Physics Frontiers, Northwest University, Xi'an, Shaanxi 710127, China.
The full-dimensional potential energy surface (PES) for the photodissociation of HNCS in the S(″) electronic state has been built up by the neural network method based on more than 48,000 points, which were calculated at the multireference configuration interaction level with Davidson correction using the augmented correlation consistent polarized valence triple-ζ basis set. It was found that two minima, namely, and isomers of HNCS, and seven stationary points exist on the S PES for the three dissociation pathways: HNCS(S) → H + NCS/HNC + S(D)/HN(Δ) + CS(Σ). The dissociation energies of two lowest product channels H + NCS and HNC + S(D) calculated on the PES are in good agreement with experimental results, validating the high accuracy of the PES.
View Article and Find Full Text PDFJ Vis
January 2025
Department of Psychology, New York University, New York, NY, USA.
Active object recognition, fundamental to tasks like reading and driving, relies on the ability to make time-sensitive decisions. People exhibit a flexible tradeoff between speed and accuracy, a crucial human skill. However, current computational models struggle to incorporate time.
View Article and Find Full Text PDFJ Neural Transm (Vienna)
January 2025
Neurology Department, LR18SP03, Razi University Hospital, Tunis, Tunisia.
Amyotrophic Lateral Sclerosis(ALS) has traditionally been managed as a neuromuscular disorder. However, recent evidence suggests involvement of non-motor domains. This study aims to evaluate the impact of APOE and MAPT genotypes on the cognitive features of ALS.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: Heterogeneity in the progression of clinical dementia poses a significant challenge, impeding the effectiveness of current therapies for Alzheimer's disease (AD). To decipher the molecular mechanisms governing heterogeneity in AD progression that remains a critical knowledge gap precluding rational therapeutic design, we investigated the biochemical and biophysical properties of tau present in the inferior temporal gyrus (ITG) and prefrontal cortex (PFC) brain regions of AD patients who had varying disease progression rates. To explore gene expression changes in the ITG which are associated with tau pathology and cognitive decline, we used RNA sequencing for molecular characterization of patients displaying tau and clinical heterogeneity.
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