AI Article Synopsis
- A new method using palladium as a catalyst has been developed for creating furans and cyclopropanes from cyclic 1,3-diketones or 1,3-indandione in combination with various alkenes.
- This process achieves moderate to good yields and shows excellent selectivity for the desired products.
- The method is highly efficient, works well with different types of alkene substrates, and tolerates a variety of functional groups.
Article Abstract
A practical and effective palladium-catalyzed C-H activation/alkene insertion/annulation has been reported for the synthesis of furans and cyclopropanes from cyclic 1,3-diketones or 1,3-indandione and diverse alkenes, resulting in moderate to good yields. This protocol demonstrates excellent selectivity and is well-compatible with a wide range of alkene substrates, exhibiting exceptional regioselectivities, high efficiency, and good functional group tolerance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4cc01964d | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Palladium-Catalyzed Intramolecular C-H Amination via Oxidative Coupling on Indole Derivatives: Access to 11-Benzo[4,5]imidazo[1,2-]indoles.
Org Lett
December 2024
Division of Medicinal Chemistry, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.
A novel palladium-catalyzed intramolecular C-H amination via oxidative coupling exploiting inactivated N-substituted aryl amines on indoles for the one-pot synthesis of novel 11-benzo[4,5]imidazo[1,2-]indole derivatives is reported. The optimized reaction conditions accommodated a wide range of electronic variations on both the indole and the pendant aryl amine ring, resulting in products with good to excellent yields.
View Article and Find Full Text PDFSynthesis of Tetracyclic-Fused Dihydroindeno[2,1-]chromenes via Palladium-Catalyzed Alkyne Insertion and C-H Bond Activation.
J Org Chem
December 2024
Jiangsu Key Laboratory for Chemistry of Low Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian 223300, China.
An unprecedented Pd-catalyzed cascade alkyne insertion/Heck/C-H activation reaction of -iodophenyl alkenyl ethers and diarylacetylenes has been developed. Diversified tetracyclic-fused dihydroindeno[2,1-]chromenes bearing a quaternary center were constructed in an efficient, straightforward, and atom-economic way with good to excellent yields. The protocol features high bonding efficiency, operational simplicity, broad substrate scope, and easy scale-up.
View Article and Find Full Text PDFSynthesis of continuously substituted quinolines from -alkenyl aromatic isocyanides by palladium-catalyzed intramolecular imidoylative 6- cyclization.
Chem Commun (Camb)
December 2024
Department of Chemistry, School of Pharmacy, Air Force Medical University, Xi'an, 710032, China.
An efficient synthesis of continuously substituted quinoline derivatives palladium-catalyzed intramolecular 6- imidoylative cyclization of -alkenyl aryl isocyanides with (hetero)aryl halides or vinylic triflates has been developed. The reaction proceeds through the concerted metalation-deprotonation (CMD) mechanism by activation of a vinyl C-H bond with imidoylpalladium assisted by the carboxylate.
View Article and Find Full Text PDFPalladium-Catalyzed Fluorinated Olefination of Aromatics.
Org Lett
December 2024
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
Palladium-mediated, ligand-promoted C-H fluorinated olefination of aromatic derivatives is reported employing 2-bromo-3,3,3-trifluoropropene (BTP) as the fluorinating reagent. Bioactive compounds, such as Isatin, exhibited excellent compatibility with this reaction, underscoring the significance of this methodology for the synthesis of important derivatives.
View Article and Find Full Text PDFPalladium-catalyzed aerobic homocoupling of aliphatic olefins to dienes: evidence for rate-limiting concerted metalation-deprotonation.
Chem Sci
December 2024
Centre for Membrane Separations, Adsorption, Catalysis and Spectroscopy for Sustainable Solutions (cMACS), KU Leuven 3001 Leuven Belgium
Palladium(ii)-catalyzed dehydrogenative coupling of aliphatic olefins would enable an efficient route to (conjugated) dienes, but remains scarcely investigated. Here, 2-hydroxypyridine (2-OH-pyridine) was found to be an effective ligand for Pd(ii) in the activation of vinylic C(sp)-H bonds. While reoxidation of Pd(0) is challenging in many catalytic oxidations, one can avoid in this reaction that the reoxidation becomes rate-limiting, even under ambient O pressure, by working in coordinating solvents.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!