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Effects of corn oil ingestion on the intestinal mucosa of normal dogs.
Front Vet Sci
December 2024
Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Introduction: We assessed corn oil's oral effectiveness in detecting small bowel changes in healthy dogs through ultrasonography, endoscopy, and histopathology. We hypothesize that corn oil ingestion will not significantly increase the visibility of lymphatics and lacteals in healthy dogs.
Methods: Five healthy male beagles were studied under institutional guidelines.
N-acetyl-L-tryptophan provides radioprotection to mouse and primate models by antagonizing the TRPV1 receptor and substance P inhibition.
Int J Radiat Biol
January 2025
Department of Radiation Biotechnology, Institute of Nuclear Medicine and Allied Sciences, Delhi, India.
Purpose: The present study was carried out to evaluate the radioprotective activities of N-acetyl-L-tryptophan (L-NAT) using rodent and non-human primate (NHP) models.
Materials And Methods: The antagonistic effect of L-NAT on the Transient receptor potential vanilloid-1 (TRPV1) receptor and substance P inhibition was determined using molecular docking and Elisa assays. The in radioprotective activity of L-NAT was evaluated using whole-body survival assays in mice and NHPs.
The endocannabinoid system in bovine tissues: characterization of transcript abundance in the growing Holstein steer.
BMC Vet Res
October 2024
USDA-ARS Forage-Animal Production Research Unit, University of Kentucky Campus, 1100 S. Limestone Rd. N220 Ag. Science North, Lexington, KY, 40546, USA.
Background: The endocannabinoid system (ECS) is highly integrated with seemingly all physiological and pathophysiological processes in the body. There is increasing interest in utilizing bioactive plant compounds, for promoting health and improving production in livestock. Given the established interaction between phytochemicals and the ECS, there are many opportunities for identification and development of therapies to address a range of diseases and disorders.
View Article and Find Full Text PDFLabrafac MC60 is an efficacious intestinal permeation enhancer for macromolecules: Comparisons with Labrasol® ALF in ex vivo and in vivo rat studies.
Int J Pharm
August 2024
UCD School of Veterinary Medicine and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address:
Labrafac™ MC60 (glycerol monocaprylocaprate) is a lipid-based excipient used in oral formulations as a solubiliser. Due to the high proportions of established permeability enhancers, caprylate (C) and caprate (C), in Labrafac™ MC60, we hypothesised that it might behave as an intestinal permeation enhancer. We therefore evaluated this using two paracellular markers (ex vivo) and insulin (in vivo) as model molecules.
View Article and Find Full Text PDF[Transient jejunal intussusception as an incidental finding on MRI].
Rofo
January 2025
Department of Radiology, Bundeswehrkrankenhaus Hamburg, Hamburg, Germany.
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