AI Article Synopsis
- Autoimmune encephalitis (AE) is challenging to manage, and this study evaluates the Clinical Assessment Scale in Autoimmune Encephalitis (CASE) against the modified Rankin scale (mRS) for effectiveness in monitoring AE patients.
- In the study of 20 AE patients, the CASE score showed better sensitivity for detecting clinical changes than the mRS, and a systematic review indicated widespread use especially in Asian populations, confirming its reliability.
- Although the study has limitations like a small sample size, the CASE score proves to be a useful tool for AE monitoring, suggesting the need for further research in diverse groups to confirm its broader relevance and improve treatment approaches.
Article Abstract
Background: Autoimmune encephalitis (AE) poses significant challenges in clinical management, requiring effective monitoring tools for therapeutic success and relapse detection. This study aims to assess the Clinical Assessment Scale in Autoimmune Encephalitis (CASE) as compared to the modified Rankin scale (mRS) in evaluating AE patients and to determine the real-world adoption of the CASE score.
Methods: A retrospective cohort study was conducted on 20 AE patients, assessing clinical data including symptomatology, diagnostic findings, and therapeutic regimens. Furthermore, we performed a systematic review on the test performance criteria and the real-world use of the CASE score.
Results: The CASE score showed a higher sensitivity in detecting clinical changes compared to the mRS, with a significant correlation between the two scales throughout the disease course (r = 0.85, p < 0.01). A systematic review of 150 articles revealed widespread adoption of the CASE score, especially in Asian populations, demonstrating high reliability and internal consistency.
Discussion: Despite limitations such as retrospective design and small sample size, our findings underscore the CASE score's utility in both clinical practice and research settings. The CASE score emerges as a valuable tool for monitoring AE patients, offering improved sensitivity over existing scales like the mRS. Further validation studies in diverse populations are warranted to establish its broader applicability and inform future therapeutic interventions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11470881 | PMC |
| http://dx.doi.org/10.1007/s10072-024-07642-1 | DOI Listing |
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