To report treatment patterns and quality of life (QoL) in HER2-negative advanced breast cancer patients. Data were drawn from a cross-sectional survey in Europe and USA. Hormone plus targeted therapy was the most frequent first-line (1L, 62%) and second-line (2L, 45%) treatment for HR+/HER2-patients. Chemotherapy was most frequent at third-line or greater (3L+, 39%) for HR+/HER2- patients, 2L (51%) and 3L+ (48%) for triple negative breast cancer (TNBC) patients. Time to progression was 13.8 (2L) and 11.0 (3L+) months for HR+/HER2- patients. No comparisons were observed for TNBC patients. EQ-5D-5L scores were highest in patients at 1L and lowest at 3L+. Reduced QoL and treatment response were reported in patients at later lines of therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486049 | PMC |
| http://dx.doi.org/10.2217/fon-2022-1228 | DOI Listing |
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