Pyridazinones are classical molecules that occupy an important place in heterocyclic chemistry, and since their discovery, they have been widely developed. The introduction of new functional groups into pyridazinone structures has enabled the synthesis of a large diversity of compounds. The pharmacological and agrochemical importance of pyridazinone derivatives has aroused the interest of chemists and directed their research toward the synthesis of new compounds with the aim of improving their biological effectiveness. In this review, we have compiled and discussed the different synthetic routes, reactivity, and pharmacological and agrochemical applications of the pyridazinone ring.
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http://dx.doi.org/10.2174/0113895575287746240528072330 | DOI Listing |
Sci Rep
January 2025
School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand.
A nanoemulsion was fabricated from Cananga odorata essential oil (EO) and stabilized by incorporation of Tween 80 using ultrasonication. The major constituents of the EO were benzyl benzoate, linalool, and phenylmethyl ester. Differing sonication amplitude (20-60%) and time (2-10 min) were assessed for effects on nanoemulsion droplet size and polydispersity index (PI).
View Article and Find Full Text PDFMolecules
January 2025
College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
A series of novel triazone derivatives containing aldehyde hydrazone or ketone hydrazone moieties were designed, synthesized and their biological activities were investigated against , , , , and 14 Kinds of fungi. Most of the aldehyde hydrazone exhibited excellent insecticidal activities against . In particular, the aphicidal activities of compounds (35%) and (30%) were equivalent to pymetrozine (30%) at 5 mg/kg.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Sino-American Biological Control Laboratory, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Imidacloprid, a widely used neonicotinoid insecticide, targets insect pests but also affects natural enemies. However, the effects of neonicotinoid insecticides on closely related insects remain unclear. We evaluated the harmful effects of imidacloprid on the phytophagous and predaceous .
View Article and Find Full Text PDFPLoS One
January 2025
Department of Computer Science and Engineering, University of Chittagong, Chattogram, Bangladesh.
Rice blast, caused by Magnaporthe oryzae, is one of the most destructive fungal diseases in rice, resulting in major economic losses worldwide. Genetic and genomic studies have identified key genes and proteins, such as AvrPik variants and MAX proteins, that are crucial for the pathogen's virulence. These effector proteins interact with specific alleles of the Pik gene family on rice chromosome 11, modulating the host's immune response.
View Article and Find Full Text PDFBMC Genomics
January 2025
Program in Public Health, College of Health Sciences, University of California, Irvine, California, USA.
Background: The resurgence of Anopheles funestus, a dominant vector of human malaria in western Kenya was partly attributed to insecticide resistance. However, evidence on the molecular basis of pyrethroid resistance in western Kenya is limited. Here, we reported metabolic resistance mechanisms and demonstrated that multiple non-coding Ribonucleic Acids (ncRNAs) could play a potential role in An.
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