Metasurfaces made of subwavelength silicon nanopillars provide unparalleled capacity to manipulate light, and have emerged as one of the leading platforms for developing integrated photonic devices. In this study, we report on a compact, passive approach based on planar metasurface optics to generate large optical trap arrays. The unique configuration is achieved with a meta-hologram to convert a single incident laser beam into an array of individual beams, followed up with a metalens to form multiple laser foci for single rubidium atom trapping. We experimentally demonstrate two-dimensional arrays of 5 × 5 and 25 × 25 at the wavelength of 830 nm, validating the capability and scalability of our metasurface design. Beam waists ∼1.5 µm, spacings (about 15 µm), and low trap depth variations (8%) of relevance to quantum control for an atomic array are achieved in a robust and efficient fashion. The presented work highlights a compact, stable, and scalable trap array platform well-suitable for Rydberg-state mediated quantum gate operations, which will further facilitate advances in neutral atom quantum computing.
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Sci Rep
January 2025
Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA, 01003, USA.
X-ray crystallography is one of the leading tools to analyze the 3-D structure, and therefore, function of proteins and other biological macromolecules. Traditional methods of mounting individual crystals for X-ray diffraction analysis can be tedious and result in damage to fragile protein crystals. Furthermore, the advent of multi-crystal and serial crystallography methods explicitly require the mounting of larger numbers of crystals.
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Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
αβT cells protect vertebrates against many diseases, optimizing surveillance using mechanical force to distinguish between pathophysiologic cellular alterations and normal self-constituents. The multi-subunit αβT-cell receptor (TCR) operates outside of thermal equilibrium, harvesting energy via physical forces generated by T-cell motility and actin-myosin machinery. When a peptide-bound major histocompatibility complex molecule (pMHC) on an antigen presenting cell is ligated, the αβTCR on the T cell leverages force to form a catch bond, prolonging bond lifetime, and enhancing antigen discrimination.
View Article and Find Full Text PDFSubcell Biochem
December 2024
Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), and Department of Molecular Biology, Universidad Autónoma de Madrid, Madrid, Spain.
Structural biology techniques have greatly contributed to unveiling the interplay between molecular structure, physico-chemical properties, and biological function of viruses. In recent years, classic structural approaches are being complemented by single-molecule techniques such as atomic force microscopy and optical tweezers to study physical features of viral particles that are not accessible to classic structural techniques. Among these features are mechanical properties such as stiffness, intrinsic elasticity, tensile strength, and material fatigue.
View Article and Find Full Text PDFSubcell Biochem
December 2024
Centro de Tecnologías Físicas, Universitat Politècnica de València, Valencia, Spain.
A virus is a complex molecular machine that propagates by channeling its genetic information from cell to cell. Unlike macroscopic engines, it operates in a nanoscopic world under continuous thermal agitation. Viruses have developed efficient passive and active strategies to pack and release nucleic acids.
View Article and Find Full Text PDFBiomech Model Mechanobiol
December 2024
Department of Biomedical Engineering, Virginia Commonwealth University, 401 W. Main St., Richmond, VA, 23284, USA.
Embryonic development, wound healing, and organogenesis all require assembly of the extracellular matrix protein fibronectin (FN) into insoluble, viscoelastic fibrils. FN fibrils mediate cell migration, force generation, angiogenic sprouting, and collagen deposition. While the critical role of FN fibrils has long been appreciated, we still have an extremely poor understanding of their mechanical properties and how these mechanical properties facilitate cellular responses.
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