Multi-pass cell (MPC) compressors have proven to be the method of choice for compression of high average power long-pulse Yb lasers. Yet, generating sub-30 fs pulses at high pulse energy with compact and simple components remains a challenge. This work demonstrates an efficient and cost-effective approach for nonlinear pulse compression at high pulse energy using a hybrid air-bulk MPC. By carefully balancing the relative nonlinear contributions of ambient air and fused silica, we achieve strong spectral broadening without dispersion engineering or pressure-control inside the cell at 400-µJ pulse energy. In this way, we compress pulses from 220 fs to 27 fs at 40.3 W of average power (100 kHz repetition rate), enhancing the peak power from 1.6 GW to 10.2 GW while maintaining 78% of the energy within the main pulse. Our approach combines the strengths of gas-filled and bulk compression schemes and exhibits excellent overall optical transmission (91%) and spectral uniformity. Moreover, we utilize the INSIGHT technique to investigate spatio-temporal couplings and geometrical aberrations of the compressed pulse. Our results demonstrate remarkable temporal homogeneity, with an average Strehl ratio of 0.97 consistently observed throughout the entire spectral profile. Additionally, all spectrally-integrated Zernike coefficients for geometrical aberrations maintain values below 0.02λ.
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http://dx.doi.org/10.1364/OE.513732 | DOI Listing |
Transplant Proc
December 2024
Heart Failure and Transplantation Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain; Department of Cardiology, Hospital Universitario y Politécnico La Fe, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain; Department of Medicine, Universidad de Valencia, Spain.
Background: A high percentage of patients with congenital heart diseases (CHD) reach adulthood and, over time, require heart transplantation (HTx) or combined heart-lung transplantation (HLTx). Among CHD, there are subgroups associated with a higher risk.
Methods: Retrospective analysis of HTx and HLTx in CHD patients.
Br J Gen Pract
December 2024
University College London, London, United Kingdom.
Background: Evidence on whether general practice rates of investigation in symptomatic patients using chest x-ray (CXR) affects outcomes is equivocal.
Aim: Determine if there is an association between rates of general practice (GP) requested CXR and lung cancer outcomes.
Design And Setting: Retrospective observational study (England) Methods: Cancer registry data for patients diagnosed with lung cancer 2014-2018 was linked to data on GP CXRs 2013-2017.
Int J Biol Macromol
December 2024
Integrated Transformation and Renewable Matter TIMR (UTC/ESCOM), University of Technology of Compiegne- Alliance Sorbonne University, Centre of Research of Royallieu, Rue du docteur Schweitzer, CS 60319, 60203 Compiegne, France. Electronic address:
Extracting The extraction of cellulose and lignin from biomass is essential for the development of sustainable bio-based materials. This study examines the effects of physical pretreatment techniques-ultrasound (US), pulsed electric fields (PEF), and high-voltage electrical discharges (HVED)-on the efficiency of alkali treatment for cellulose and lignin extraction from walnut shells. The primary objective was to enhance extraction yields and improve extract quality while evaluating the effectiveness of these methods.
View Article and Find Full Text PDFTalanta
December 2024
Hyphenated Mass Spectrometry Laboratory, Faculty of Science, University of Technology Sydney, PO Box 123, Broadway, 2007 NSW, Australia; School of Life Sciences, Faculty of Science, University of Technology Sydney, PO Box 123, Broadway, 2007 NSW, Australia.
The importance of sample preparation selection if often overlooked particularly for untargeted multi-omics approaches that gained popularity in recent years. To minimize issues with sample heterogeneity and additional freeze-thaw cycles during sample splitting, multiple -omics datasets (e.g.
View Article and Find Full Text PDFESC Heart Fail
December 2024
Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Aims: Patients with cardiomyopathies are a heterogeneous group of patients who experience high morbidity and mortality. Early cardiac assessment and intervention with access to genetic counselling in a multidisciplinary Cardiomyopathy Clinic may improve outcomes and prevent progression to advanced heart failure.
Methods And Results: Our prospective cohort study was conducted at a multidisciplinary Cardiomyopathy Clinic with 421 patients enrolled (42.
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