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Highly integrated automatic injection terahertz microfluidic biosensor based on metasurface and LT-GaAs photoconductive antenna. | LitMetric

AI Article Synopsis

  • - A new terahertz (THz) biosensor is developed using low-temperature gallium arsenide (LT-GaAs) thin film technology, streamlining the complexity of traditional THz time-domain spectroscopy systems for wave generation and detection.
  • - The design features a latch type metasurface that creates a stable resonance absorption peak at 0.6 THz that is unaffected by polarization, while also integrating microfluidics for automatic fluid injection to minimize interference from hydrogen bond absorption in liquid.
  • - Successful tests were conducted to detect bacteria of various sizes and two types of breast cancer cells, demonstrating the biosensor's ability to distinguish between cancer cell types through changes in resonance peak amplitude and position, showcasing its potential for sensitive and rapid

Article Abstract

In this paper, a highly integrated terahertz (THz) biosensor is proposed and implemented, which pioneered the preparation of low-temperature gallium arsenide (LT-GaAs) thin film photoconductive antenna (PCA) on the sensor for direct generation and detection of THz waves, simplifying complex terahertz time-domain spectroscopy (THz-TDS) systems. A latch type metasurface is deposited in the detection region to produce a resonance absorption peak at 0.6 THz that is independent of polarisation. Microfluidics is utilised and automatic injection is incorporated to mitigate the experimental effects of hydrogen bond absorption of THz waves in aqueous-based environment. Additionally, cell damage is minimised by regulating the cell flow rate. The biosensor was utilised to detect the concentration of three distinct sizes of bacteria with successful results. The assay was executed as a proof of concept to detect two distinct types of breast cancer cells. Based on the experimental findings, it has been observed that the amplitude and blueshift of the resonance absorption peaks have the ability to identify and differentiate various cancer cell types. The findings of this study introduce a novel approach for developing microfluidic THz metasurface biosensors that possess exceptional levels of integration, sensitivity, and rapid label-free detection capabilities.

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Source
http://dx.doi.org/10.1364/OE.518638DOI Listing

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