The persistence of Vibrio cholerae, biotype el tor, in a patient treated with trimethoprim-sulfamethoxazole was due to the acquisition of a conjugative resistance plasmid. The plasmid, with a molecular size of 72 megadaltons, belonged to incompatibility group 6-C and conferred resistance to ampicillin, chloramphenicol, sulfonamide, and trimethoprim.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC176256PMC
http://dx.doi.org/10.1128/AAC.27.2.280DOI Listing

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