This work focuses on the prediction and comparison of the fatigue life of topologically optimized pads in an externally adjustable fluid film (EAFF) bearing. It integrates one-way/two-way fluid-structure interaction analysis, topological optimization (TO), and design modifications of the pad of an externally adjustable fluid film bearing. The major goal is to create an optimum pad design that minimizes weight and maintains structural integrity, and then to predict and compare the fatigue life of these alternative designs. The outcomes of the present study are as follows: (i) Two-way FSI results show a decrease of 65.64% in hydrodynamic fluid film pressure when compared to one-way FSI results because they take into account modifications in the fluid region's geometry caused by pad deformation; (ii) even though the maximum pad deformation in optimized pad geometry (Type-4) resulting from oil film pressure is relatively small (0.0036551 mm), the influence of pad deformation on the fluid domain due to hydrodynamic fluid film pressure cannot be understated; and (iii) when comparing the TO technique's results with fatigue life results, four elongated holes in the radial direction (Type-4) are most appropriate.
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http://dx.doi.org/10.1038/s41598-024-64259-2 | DOI Listing |
Adv Sci (Weinh)
January 2025
State Key Laboratory of Fluid Power and Mechatronic Systems, Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310058, China.
Bioinspired supramolecular architectonics is attracting increasing interest due to their flexible organization and multifunctionality. However, state-of-the-art bioinspired architectonics generally take place in solvent-based circumstance, thus leading to achieving precise control over the self-assembly remains challenging. Moreover, the intrinsic difficulty of ordering the bio-organic self-assemblies into stable large-scale arrays in the liquid environment for engineering devices severely restricts their extensive applications.
View Article and Find Full Text PDFComput Methods Biomech Biomed Engin
January 2025
Jiangsu Key Laboratory for Design and Manufacture of Micro/Nano Biomedical Instruments Micro-Tech (Nanjing) Co., Ltd, Nanjing, Jiangsu Province, China.
Bronchial stenosis impacts cough mechanisms and respiratory function. This study used MIMICS and Fluent to construct and simulate a 3D airway model of an elderly female patient with bronchial stenosis. Utilizing dynamic mesh and fluid-structure interaction, airflow during coughing was analyzed, including velocity, wall shear stress, and deformation.
View Article and Find Full Text PDFBiomater Adv
January 2025
INM-Leibniz Institute for New Materials, Saarbrucken, Germany; Chemistry Department, Saarland University, 66123 Saarbrucken, Germany. Electronic address:
Living Therapeutic Materials (LTMs) are a promising alternative to polymeric drug carriers for long term release of biotherapeutics. LTMs contain living drug biofactories that produce the drug using energy sources from the body fluids. To clarify their application potential, it is fundamental to adapt biocompatibility and cytotoxicity assays applied from non-living biomaterials and therapeutics to evaluate how LTMs interact with host cells.
View Article and Find Full Text PDFAnn Med
December 2025
Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Purpose: To evaluate levels of 3 tear-soluble neuropeptides in dry eye patients and to identify the correlations with clinical signs and symptoms.
Methods: A total of 16 dry eye patients and 12 healthy volunteers were enrolled. Dry eye disease (DED) diagnosis was based on the 2017 Report of the Tear Film & Ocular Surface Society International Dry Eye Workshop (TFOS DEWS II).
Eur J Pharm Sci
January 2025
University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia. Electronic address:
Dry eye disease is a multifactorial condition characterized by a loss of homeostasis of the tear film. Among the various treatment approaches, the application of ophthalmic oil-in-water nanoemulsions with incorporated anti-inflammatory drugs represents one of the most advanced approaches. However, the liquid nature of nanoemulsions limits their retention time at the ocular surface.
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