AI Article Synopsis
- Tumor cells change their metabolism to support their rapid division, providing insights into how metabolism affects other biological processes.
- Research on cancer metabolism has uncovered connections to areas like tissue injury, embryonic development, and virus infection.
- The study of cancer metabolism enriches our understanding of metabolism in general, suggesting potential for future discoveries across various scientific fields.
Article Abstract
Tumor cells divide rapidly and dramatically alter their metabolism to meet biosynthetic and bioenergetic needs. Through studying the aberrant metabolism of cancer cells, other contexts in which metabolism drives cell state transitions become apparent. In this work, we will discuss how principles established by the field of cancer metabolism have led to discoveries in the contexts of physiology and tissue injury, mammalian embryonic development, and virus infection. We present specific examples of findings from each of these fields that have been shaped by the study of cancer metabolism. We also discuss the next important scientific questions facing these subject areas collectively. Altogether, these examples demonstrate that the study of "cancer metabolism" is indeed the study of cell metabolism in the context of a tumor, and undoubtedly discoveries from each of the fields discussed here will continue to build on each other in the future.
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| http://dx.doi.org/10.1101/cshperspect.a041554 | DOI Listing |
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