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Integrated proteomics and connectivity map-based analysis reveal compounds with a potential antiviral effect against Japanese encephalitis virus infection in a mouse model.
FEBS J
December 2024
Laboratory of Virology, Regional Centre for Biotechnology, Faridabad, India.
Japanese encephalitis virus (JEV) is the leading causative agent of viral encephalitis in India and contributes to a significant disease burden in South Asian countries. However, no antiviral treatment is available against JEV-induced encephalitis, highlighting the urgent need for novel therapeutic approaches. Repurposing or repositioning drugs was found to be more economical and practical in the current drug development scenario.
View Article and Find Full Text PDFPathogenic role for CD101-negative neutrophils in the type I interferon-mediated immunopathogenesis of tuberculosis.
Cell Rep
December 2024
Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA. Electronic address:
Neutrophils are vital for immunity against Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), yet their heterogeneous nature suggests a complex role in TB pathogenesis. Here, we identify two distinct neutrophil populations based on CD101 expression, highlighting their divergent roles in TB. CD101-negative (CD101) neutrophils, which resemble immature, pro-inflammatory granulocytes, exhibit reduced Mtb phagocytosis compared to their mature, CD101-positive (CD101) counterparts.
View Article and Find Full Text PDFHost-directed therapies modulating innate immunity against infection in hematologic malignancies.
Blood Rev
December 2024
Faculty of Life and Environmental Sciences, Biomedical Center, University of Iceland, Reykjavik, Iceland. Electronic address:
Patients with hematologic malignancies (HM) are highly susceptible to bloodstream infection (BSI), particularly those undergoing treatments such as chemotherapy. A common and debilitating side effect of chemotherapy is oral and intestinal mucositis. These Patients are also at high risk of developing sepsis, which can arise from mucosal barrier injuries and significantly increases mortality in these patients.
View Article and Find Full Text PDFBovine NMRAL2 Protein Blunts Nitric Oxide Production and Inflammatory Response in Infected Bovine Lung Epithelial Cells.
Cells
November 2024
National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Tuberculosis (TB), primarily caused by () and (), remains the leading cause of death from a single infectious agent globally. Intracellular survival is crucial for their virulence; yet, the underlying mechanisms are not fully understood. This study aimed to demonstrate the significance of a previously unannotated bovine gene ENSBTAG00000011305 in intracellular survival.
View Article and Find Full Text PDFEnhanced Immune Responses Against Through Heat-Killed BCG with Squalene-in-water Emulsion Adjuvant.
Indian J Microbiol
December 2024
Beijing Key Laboratory of Organ Transplantation and Immunology Regulation, The Eighth Medical Centre, Chinese PLA General Hospital, Beijing, 100091 China.
The increasing challenge of drug-resistant tuberculosis (TB) calls for the development of innovative therapeutic strategies, highlighting the potential of adjunctive immunotherapies that are both cost-effective and safe. Host-directed therapy (HDT) using immunomodulators shows promise in enhancing treatment efficacy by modulating immune responses, thereby shortening the duration of therapy and reducing drug resistance risks. This study investigated the immunomodulatory potential of combining Heat-killed Bacillus Calmette-Guérin (hBCG) with a Squalene-based oil-in-Water Emulsion (SWE) adjuvant against TB.
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