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Less Is More: Advanced Diagnostic Tests and Smarter Algorithms Are Urgently Needed in Encephalitis With Absent Cerebrospinal Fluid Pleocytosis.
Clin Infect Dis
December 2024
Department of Internal Medicine, University Hospital Basel, Basel, Switzerland.
Response to Commentary on "Structural characterization of SLYM - a 4th meningeal membrane" by Julie Siegenthaler and Christer Betsholtz.
Fluids Barriers CNS
September 2024
Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Histological studies have for decades documented that each of the classical meningeal membranes contains multiple fibroblast layers with distinct cellular morphology. Particularly, the sublayers of the arachnoid membranes have received attention due to their anatomical complexity. Early studies found that tracers injected into the cerebrospinal fluid (CSF) do not distribute freely but are restricted by the innermost sublayer of the arachnoid membrane.
View Article and Find Full Text PDFCommentary on "Structural characterization of SLYM - a 4th meningeal membrane".
Fluids Barriers CNS
September 2024
Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
For centuries, the meninges have been described as three membranes: the inner pia, middle arachnoid and outer dura. It was therefore sensational when in early 2023 Science magazine published a report of a previously unrecognized - 4th - meningeal membrane located between the pia and arachnoid. Multiple features were claimed for this new membrane: a single cell layer marked by the transcription factor Prox1 that formed a barrier to low molecular weight substances and separated the subarachnoid space (SAS) into two fluid-filled compartments, not one as previously described.
View Article and Find Full Text PDFBreaking barriers: addressing inequities in Alzheimer's disease diagnosis and treatment in Africa.
Ann Med Surg (Lond)
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Oli Health Magazine Organization, Research and Education.
Introduction: Alzheimer's disease represents a substantial and escalating public health threat across Africa. Alzheimer's disease leads to substantial cognitive impairment and memory loss, placing a heavy burden on the affected individuals and their families, friends, and caregivers. It affects 2.
View Article and Find Full Text PDFEnhancing the validity and applicability of study for health-related quality of life in patients with conditions affecting the hand: meta-analysis.
Br J Surg
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Department of Neurosurgery, Second Xiangya Hospital, Central South University, Changsha, China.
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