A cysteine-based fluorous trapping reagent, RfCYS, was developed. RfCYS formed adducts with soft and hard electrophilic reactive metabolites. These fluorous-tagged adducts were purified both fluorous solid-phase extraction and the direct injection method. The highly sensitive mass spectrometric detection of an unprecedented adduct of the ticlopidine metabolite was realized.
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| http://dx.doi.org/10.1039/d4ay00577e | DOI Listing |
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