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Understanding pulmonary hypertension: the need for an integrative metabolomics and transcriptomics approach. | LitMetric

AI Article Synopsis

  • Pulmonary hypertension (PH) is a serious condition with mean pulmonary arterial pressure over 20 mm Hg, linked to various health issues and associated with high morbidity and mortality, making it a global concern.
  • Advances have been made in understanding the disease, but key molecular mechanisms are still unclear, and there are challenges with diagnostics and targeted treatments.
  • This review focuses on new insights gained from transcriptomics and metabolomics in PH patients and emphasizes the importance of an integrative multi-omics approach to better understand the disease at a molecular level, while also discussing common challenges in these studies.

Article Abstract

Pulmonary hypertension (PH), characterised by mean pulmonary arterial pressure (mPAP) >20 mm Hg at rest, is a complex pathophysiological disorder associated with multiple clinical conditions. The high prevalence of the disease along with increased mortality and morbidity makes it a global health burden. Despite major advances in understanding the disease pathophysiology, much of the underlying complex molecular mechanism remains to be elucidated. Lack of a robust diagnostic test and specific therapeutic targets also poses major challenges. This review provides a comprehensive update on the dysregulated pathways and promising candidate markers identified in PH patients using the transcriptomics and metabolomics approach. The review also highlights the need of using an integrative multi-omics approach for obtaining insight into the disease at a molecular level. The integrative multi-omics/pan-omics approach envisaged to help in bridging the gap from genotype to phenotype is outlined. Finally, the challenges commonly encountered while conducting omics-driven studies are also discussed.

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Source
http://dx.doi.org/10.1039/d3mo00266gDOI Listing

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