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The role of calcium stores in long-term potentiation and synaptic tagging and capture in mouse hippocampus. | LitMetric

The role of calcium stores in long-term potentiation and synaptic tagging and capture in mouse hippocampus.

Philos Trans R Soc Lond B Biol Sci

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System , Toronto, Ontario M5G 1X5, Canada.

Published: July 2024

AI Article Synopsis

Article Abstract

The roles of Ca-induced calcium release in synaptic plasticity and metaplasticity are poorly understood. The present study has addressed the role of intracellular Ca stores in long-term potentiation (LTP) and a form of heterosynaptic metaplasticity known as synaptic tagging and capture (STC) at CA1 synapses in mouse hippocampal slices. The effects of two compounds, ryanodine and cyclopiazonic acid (CPA), were examined on LTP induced by three distinct induction protocols: weak (w), compressed (c) and spaced (s) theta-burst stimulation (TBS). These compounds did not significantly affect LTP induced by the wTBS (one episode of TBS; 25 stimuli) or cTBS (three such episodes with a 10 s inter-episode interval (IEI); 75 stimuli) but substantially inhibited LTP induced by a sTBS (10 min IEI; 75 stimuli). Ryanodine and CPA also prevented a small heterosynaptic potentiation that was observed with the sTBS protocol. Interestingly, these compounds also prevented STC when present during either the sTBS or the subsequent wTBS, applied to an independent input. All of these effects of ryanodine and CPA were similar to that of a calcium-permeable AMPA receptor blocker. In conclusion, Ca stores provide one way in which signals are propagated between synaptic inputs and, by virtue of their role in STC, may be involved in associative long-term memories. This article is part of a discussion meeting issue 'Long-term potentiation: 50 years on'.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11343308PMC
http://dx.doi.org/10.1098/rstb.2023.0241DOI Listing

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