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Adopting the Berridge et al.: Framework to understand differences in the e-cigarette policy between the Nordic countries.
Addiction
November 2024
Department for Alcohol, Tobacco and Drugs, Norwegian Institute of Public Health, Oslo, Norway.
Care Partners' Engagement in Preventing Falls for Community-Dwelling Older People With Dementia.
Gerontologist
August 2024
Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington, USA.
Background And Objectives: Little is known about how to prevent falls in community-dwelling older people with dementia. Although their care partners adopt various behaviors to prevent their falls, it is unclear if these behaviors reduce falls for those with different levels of fall risk.
Research Design And Methods: Linking the 2015 and 2016 National Health and Aging Trends Study and the 2015 National Study of Caregiving (NSOC), we identified 390 community-dwelling older people with dementia with 607 care partners.
Advocating for Generalizability: Accepting Inherent Variability in Translation of Animal Research Outcomes.
Annu Rev Anim Biosci
February 2024
B2 Pathology Solutions LLC, Cary, North Carolina, USA; email:
Advancing scientific discovery requires investigators to embrace research practices that increase transparency and disclosure about materials, methods, and outcomes. Several research advocacy and funding organizations have produced guidelines and recommended practices to enhance reproducibility through detailed and rigorous research approaches; however, confusion around vocabulary terms and a lack of adoption of suggested practices have stymied successful implementation. Although reproducibility of research findings cannot be guaranteed due to extensive inherent variables in attempts at experimental repetition, the scientific community can advocate for generalizability in the application of data outcomes to ensure a broad and effective impact on the comparison of animals to translation within human research.
View Article and Find Full Text PDFEnabling novel paradigms: a biological questions-based approach to human chemical hazard and drug safety assessment.
Toxicol Sci
February 2024
Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Throughput needs, costs of time and resources, and concerns about the use of animals in hazard and safety assessment studies are fueling a growing interest in adopting new approach methodologies for use in product development and risk assessment. However, current efforts to define "next-generation risk assessment" vary considerably across commercial and regulatory sectors, and an a priori definition of the biological scope of data needed to assess hazards is generally lacking. We propose that the absence of clearly defined questions that can be answered during hazard assessment is the primary barrier to the generation of a paradigm flexible enough to be used across varying product development and approval decision contexts.
View Article and Find Full Text PDFDevelopment of a behavioural framework for dementia care partners' fall risk management.
BMC Geriatr
December 2022
School of Medicine, Division of Gerontology and Geriatric Medicine, School of Public Health, Department of Health Systems and Population Health, University of Washington, Seattle, USA.
Background: Although older adults living with dementia (OLWD) are at high risk for falls, few strategies that effectively reduce falls among OLWD have been identified. Dementia care partners (hereinafter referred to as "care partners") may have a critical role in fall risk management (FRM). However, little is known about the ways care partners behave that may be relevant to FRM and how to effectively engage them in FRM.
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