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Building the brain mosaic: an expanded view. | LitMetric

Building the brain mosaic: an expanded view.

Trends Genet

Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA. Electronic address:

Published: September 2024

AI Article Synopsis

Article Abstract

The complexity of the brain is closely tied to its nature as a genetic mosaic, wherein each cell is distinguished by a unique constellation of somatic variants that contribute to functional and phenotypic diversity. Postzygotic variation arising during neurogenesis is recognized as a key contributor to brain mosaicism; however, recent advances have broadened our understanding to include sources of neural genomic diversity that develop throughout the entire lifespan, from embryogenesis through aging. Moving beyond the traditional confines of neurodevelopment, in this review, we delve into the complex mechanisms that enable various origins of brain mosaicism.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387136PMC
http://dx.doi.org/10.1016/j.tig.2024.05.008DOI Listing

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