The M muscarinic receptor (M2R) is a prototypic class A G protein-coupled receptor (GPCR). Interestingly, Fasciani et al. recently identified an internal translation start site within the M receptor mRNA, directing the expression of a C-terminal receptor fragment. Elevated during cellular stress, this polypeptide localizes to mitochondria where it inhibits oxidative phosphorylation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316642 | PMC |
| http://dx.doi.org/10.1016/j.tips.2024.05.010 | DOI Listing |
Publication Analysis
Top Keywords
muscarinic receptor
8
receptor
5
novel function
4
function muscarinic
4
receptor muscarinic
4
receptor m2r
4
m2r prototypic
4
prototypic class
4
class protein-coupled
4
protein-coupled receptor
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!