AI Article Synopsis
- Metal-based drugs can be strong fighters against cancer because they interact in special ways with the cells that cause cancer.
- Recent studies have shown how these metal drugs connect with cancer cells and what happens when they do, helping scientists learn more about their effectiveness.
- The review talks about how these drugs work, how well they can fight cancer, and ideas for making them even better in the future.
Article Abstract
Metal-based drugs hold promise as potent anticancer agents owing to their unique interactions with cellular targets. This review discusses recent advances in our understanding of the intricate molecular interactions of metal-based anticancer compounds with specific therapeutic targets in cancer cells. Advanced computational and experimental methodologies delineate the binding mechanisms, structural dynamics and functional outcomes of these interactions. In addition, the review sheds light on the precise modes of action of these drugs, their efficacy and the potential avenues for further optimization in cancer-treatment strategies and the development of targeted and effective metal-based therapies for combating various forms of cancer.
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| http://dx.doi.org/10.1016/j.drudis.2024.104055 | DOI Listing |
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