AI Article Synopsis

  • Replacing monopolar pulses with bipolar pulses during irreversible electroporation (IRE) can reduce harmful neurological effects.
  • A new neural excitation model that accounts for conductivity changes and thermal impacts during brain tumor ablation was introduced in this study.
  • Bipolar pulses significantly reduce the excitable volume of brain tissue and cause less damage to surrounding healthy tissue compared to monopolar pulses.

Article Abstract

Replacing monopolar pulse with bipolar pulses of the same energized time can minimize unnecessary neurological side effects during irreversible electroporation (IRE). An improved neural excitation model that considers dynamic conductivity and thermal effects during brain tumor IRE ablation was proposed for the first time in this study. Nerve fiber excitation during IRE ablation by applying a monopolar pulse (100 μs) and a burst of bipolar pulses (energized time of 100 μs with both the sub-pulse length and interphase delay of 1 μs) was investigated. Our results suggest that both thermal effects and dynamic conductivity change the onset time of action potential (AP), and dynamic conductivity also changes the hyperpolarization amplitude. Considering both thermal effects and dynamic conductivity, the hyperpolarization amplitude in nerve fibers located 2 cm from the tumor center was reduced by approximately 23.8 mV and the onset time of AP was delayed by approximately 17.5 μs when a 500 V monopolar pulse was applied. Moreover, bipolar pulses decreased the excitable volume of brain tissue by approximately 68.8 % compared to monopolar pulse. Finally, bipolar pulses cause local excitation with lesser damage to surrounding healthy tissue in complete tumor ablation, demonstrating the potential benefits of bipolar pulses in brain tissue ablation.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioelechem.2024.108752DOI Listing

Publication Analysis

Top Keywords

bipolar pulses
20
monopolar pulse
16
dynamic conductivity
16
thermal effects
12
neural excitation
8
brain tumor
8
tumor ablation
8
pulses energized
8
energized time
8
ire ablation
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!