Revitalizing female fertility: platelet-rich plasma - hype or hope?

Reprod Biomed Online

Department of Histology and Embryology, School of Medicine, Koc University, Istanbul, Turkey; Koç University Research Centre for Translational Medicine, Istanbul, Turkey. Electronic address:

Published: August 2024

AI Article Synopsis

  • Platelet-rich plasma (PRP) is being studied to see if it can help women who are having trouble getting pregnant.
  • Researchers are looking at how PRP might make ovaries healthier and help the lining of the uterus grow thicker.
  • There are still many questions about how well PRP works and who it helps the most, so more studies are needed to understand its effects better.

Article Abstract

Platelet-rich plasma (PRP) has gained popularity as an experimental tool in regenerative medicine, with potential applications in reproductive medicine. This review will assess the existing literature on the role of PRP in female fertility enhancement, focusing on ovarian rejuvenation and increased endometrial thickness. PRP is being explored as a treatment for recurrent implantation failure, primary ovarian insufficiency and poor ovarian response. While the influence of PRP on endometrial thickness and implantation success is postulated, its effectiveness remains the subject of debate due to protocol variability and unclear patient selection criteria. This narrative review includes 36 articles published before December 2022, and highlights the lack of comprehensive molecular studies examining the impact of PRP on reproductive capacity. This review underscores the importance of standardizing PRP preparation protocols in reproductive medicine. However, challenges persist, and there is a need for well-planned randomized controlled trials and a deeper understanding of the patient population that would gain the greatest benefit from PRP treatment. Clarifying these aspects is crucial to improve outcomes for low-prognosis patients undergoing assisted reproductive technology.

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Source
http://dx.doi.org/10.1016/j.rbmo.2024.103813DOI Listing

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